5-Amino-1MQ
5-Amino-1MQ (5-Amino-1-Methylquinolinium) is a small molecule that selectively inhibits nicotinamide N-methyltransferase (NNMT), an enzyme that becomes overexpressed in obesity, aging, and certain disease states. By blocking NNMT, 5-Amino-1MQ promotes fat loss, supports lean muscle preservation, and helps restore cellular NAD+ and methyl group availability. This 250 mcg capsule format provides a low-dose, flexible oral option suitable for customized stacking, gentle introduction, or microdosing protocols. It has gained significant interest in the metabolic research and longevity communities as one of the few oral compounds capable of producing meaningful body composition changes through a novel, non-stimulant mechanism. Unlike traditional fat burners that work through thermogenesis or appetite suppression, 5-Amino-1MQ works at the cellular metabolic level by restoring the activity of pathways that decline with age and obesity.
5-Amino-1MQ is a selective small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). NNMT methylates nicotinamide using S-adenosyl methionine (SAM) as a methyl donor, producing 1-methylnicotinamide and S-adenosyl homocysteine. When NNMT is overexpressed, as occurs in obese adipose tissue and aged muscle, it depletes both NAD+ precursors and methyl group reserves, contributing to metabolic dysfunction, fat accumulation, and impaired muscle function. By inhibiting NNMT, 5-Amino-1MQ preserves cellular NAD+ availability and SAM levels, restoring the methylation reactions and energy metabolism that decline in these tissues. In animal research, this has translated to reductions in adipose tissue, improved metabolic markers, preserved muscle mass during caloric restriction, and even regrowth of muscle tissue in aged subjects.
- Selectively inhibits NNMT to restore cellular metabolic function
- Low-dose 250 mcg capsule format ideal for flexible dosing protocols
- Convenient oral administration with no injection required
- Promotes fat loss without stimulant effects on the central nervous system
- Supports lean muscle preservation during caloric deficit
- Increases cellular NAD+ availability through indirect pathway support
- Preserves methyl group reserves for healthy methylation reactions
- Does not raise heart rate or blood pressure like traditional fat burners
- Supports metabolic health markers in research models
- Compatible with diet, training, and other body recomposition protocols
- Suitable for gentle introduction or microdosing approaches
- Generally well-tolerated in available research with minimal side effects reported
- Possible mild gastrointestinal effects with oral administration
- Rare reports of mild headache or fatigue
- Limited human safety data; most research is preclinical
- Theoretical concerns regarding long-term effects on methylation balance
- Unknown effects on hormonal systems with prolonged use
- Not approved for human use; sold strictly for research purposes
- Long-term safety profile in humans has not been fully established
- Not recommended for use during pregnancy or breastfeeding
- Consult a qualified medical professional before any use
Pairs naturally with NAD+, NMN, or NR for comprehensive cellular energy support Stacks with mitochondrial peptides like SS-31 and MOTS-c for metabolic research Complements HGH Frag 176-191 or Tesamorelin in fat-loss protocols Often combined with semaglutide or tirzepatide in body recomposition stacks Pairs with CJC-1295 / Ipamorelin to support muscle preservation during fat loss Best researched on an empty stomach for maximum absorption Low-dose 250 mcg format suits flexible or microdosing research protocols Multiple capsules can be combined to reach standard daily research doses Morning and pre-workout dosing common for energy and metabolic effects Cycle protocols vary; some researchers run continuous, others use 8 to 12 week cycles Store capsules in cool, dry conditions away from direct light Effects develop gradually over weeks rather than producing acute results
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| Supplier / Lab | Strength / Volume | Price | Availability | |
|---|---|---|---|---|
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HD
HD Labs
South Africa
|
10mg
1 Vial
|
R690
|
In Stock |