SS 31
SS-31, also known as Elamipretide, MTP-131, or Bendavia, is a synthetic mitochondria-targeted tetrapeptide that selectively concentrates in the inner mitochondrial membrane. It belongs to the Szeto-Schiller (SS) peptide family, named after its discoverers Hazel Szeto and Peter Schiller. SS-31 is researched extensively for its ability to restore mitochondrial function in aged or damaged cells, making it one of the most promising compounds in longevity, cardiovascular, and neurodegenerative research. Unlike most peptides that act on receptors, SS-31 works by directly stabilizing cardiolipin in the inner mitochondrial membrane, restoring the structural integrity required for efficient ATP production.
SS-31 selectively binds to cardiolipin, a unique phospholipid found exclusively in the inner mitochondrial membrane. Cardiolipin is essential for maintaining the structure of the electron transport chain and the efficient production of ATP. With aging, oxidative stress, and disease, cardiolipin becomes peroxidized and dysfunctional, leading to electron leakage, excessive reactive oxygen species (ROS) production, and impaired ATP synthesis. SS-31 stabilizes cardiolipin and prevents its peroxidation, restoring the proper architecture of the inner mitochondrial membrane. This improves electron transport chain efficiency, reduces ROS production by up to 70 percent in research models, increases ATP output, and protects mitochondria from age-related decline. Importantly, SS-31 concentrates approximately 1000-5000 times more in mitochondria than in cytoplasm, giving it remarkable selectivity for the target organelle without significant off-target effects.
- Restores mitochondrial function in aged or damaged cells
- Reduces mitochondrial reactive oxygen species production
- Improves cellular ATP output and energy production
- Stabilizes cardiolipin in the inner mitochondrial membrane
- Supports cardiovascular health and heart muscle function
- Researched for cognitive support and neuroprotection
- Shows promise in age-related macular degeneration research
- May reduce age-related muscle weakness and sarcopenia
- Supports recovery from ischemia-reperfusion injury
- Highly selective mitochondrial targeting with minimal off-target effects
- Promising compound in longevity and healthspan research
- Injection site redness, swelling, or irritation (most common reported effect)
- Mild localized pain or burning at injection site
- Possible transient headache
- Generally considered to have an excellent safety profile in clinical trials
- Low risk of systemic side effects due to mitochondrial selectivity
- Not approved for general human use; sold strictly for research purposes
- Long-term safety profile in healthy individuals has not been fully established
- Consult a qualified medical professional before any use
Pairs well with NAD+ or NMN for comprehensive mitochondrial and longevity support Stacks with MOTS-c for synergistic mitochondrial peptide research Complements Epitalon in anti-aging and longevity protocols Often combined with Humanin for mitochondrial-derived peptide research Pairs with CoQ10, PQQ, and other oral mitochondrial support supplements Researched in cardiovascular protocols alongside cardio-protective compounds Typical research dosing: 5 mg daily (subcutaneous) Some protocols use 1-3 mg daily for maintenance, 5-10 mg for active research phases Morning administration common; timing relatively flexible compared to GH peptides Reconstitute with bacteriostatic water; refrigerate after mixing Use within 2-3 weeks of reconstitution for peptide stability Light-sensitive; store reconstituted vials in dark conditions when possible Cycle protocols vary; some researchers run continuous, others use 8-12 week cycles
Select your preferred supplier and add to cart. Prices shown include VAT.
| Supplier / Lab | Strength / Volume | Price | Availability | |
|---|---|---|---|---|
|
VM
VMed
South Africa
|
40mg
1 Vial
|
R1,150
|
In Stock |